Is All CBD Water-Soluble?


Have you ever heard the phrase, “oil and water don’t combine?” In case you’re unfamiliar and haven’t seen it in motion, go forward and check it out for your self. Pour a couple of drops of oil right into a cup of water and watch what occurs—the oil separates from the water and floats to the highest. This response, or lack thereof, is because of the truth that oil molecules are much less dense than water, non-polar, and hydrophobic. Consequently, oil in its pure state shouldn’t be water-soluble. That is true for petroleum, canola oil, olive oil, and really importantly, cannabidiol (CBD) oil.

Naturally, you would possibly surprise what water solubility has to do with CBD administration, and this results in the query, how does CBD work within the physique? When you think about the truth that almost two-thirds of the human physique consists of water, the efficacy of CBD oil could be severely hampered if solely a small quantity can really be absorbed into the bloodstream, leaving a lot of it wasted. So as to treatment this problem, a number of CBD oil producers have begun to develop water-soluble CBD oils. Beneath, we’ll focus on the scientific course of behind this, and why you must solely buy CBD merchandise that are water-soluble.

The Push for Water-Soluble CBD

The push for water-soluble CBD oil is a comparatively new phenomenon impressed by the concerted efforts of vitamin, complement, and pharmaceutical firms to extend the bioavailability of CBD merchandise with a purpose to improve their efficiency and efficacy. BioCBD+ was one of many first firms to efficiently pursue this and have become the world’s first water-soluble CBD firm over four years in the past.   

  • Bioavailability – The proportion of a drug or different substance which really enters the bloodstream when launched into the physique, thus creating an energetic impact.

With out enhancements, if a drug, complement, or vitamin is in its oil or crystalline kind, roughly 10% of it is going to be absorbed as a result of its water-insoluble properties. That is extremely inefficient and drives up the associated fee for each the corporate and the patron.

To make issues worse, a big share of those medication and molecules will not be expelled, however moderately, saved in your fats. A 2007 research discovered the next:

Substances which can be poorly soluble in water and fairly soluble in fats have comparatively free entry, by way of lipid-rich mobile membranes, to the cells of all organs together with the power to cross the blood-brain and placental obstacles. Whereas their attribute lipophilicity permits medication and drugs to succeed in goal tissues, thereby producing therapeutic results within the current, present perceptions of danger could also be ignoring the likelihood that adipose accumulations of illicit medication and prescription drugs could result in future patterns of ailing well being just like these related to publicity to different classes of xenobiotic chemical substances.

It concludes that the buildup of medication in fats storage can lead to poisonous ranges, probably leading to:

  • Nausea
  • Drowsiness
  • Cravings
  • Irritation
  • Lowered cognitive functioning
  • Lowered vitality ranges

Seeing this mounting problem, pharmaceutical firms scrambled to unravel the issue. So, it’s no surprise that the CBD trade additionally started to concentrate on the bioavailability drawback with CBD by looking for processes by which they might make water soluble CBD.

What’s Water-Soluble CBD?

As talked about, not all CBD is water-soluble. Varied research point out that solely 5% to six% of CBD oil that’s insoluble will get absorbed into the system. This leads to little or no direct reduction or therapeutic advantages. The reply to this drawback was present in artificially creating “water-soluble CBD”.

You will need to word that whereas the label “water-soluble” does carry a component of reality with it, it’s not completely factual. CBD molecules can by no means totally dissolve in water. No drug or substance can obtain 100% absorption. The one theoretical method for this to be attainable could be to inject the water-soluble merchandise immediately into the bloodstream. Nonetheless, CBD could be made “water-soluble” by chemically altering it to make it extra attuned to water and thereby enhance absorption and bioavailability.

With that in thoughts, water-soluble CBD is way simpler than its base kind. Its improved bioavailability and absorption charges lead to an elevated share of CBD within the bloodstream, and thus a extra energetic therapeutic affect on the physique.  Once we say water-soluble CBD, we imply that the CBD oil has been chemically modified to be far much less hydrophobic than its pure state. It’s necessary to have an understanding of this and the various results on the physique whether or not you’re a CBD client or CBD distributor.

How is Water-Soluble CBD Made?

In case you have been so as to add oil and water right into a bottle after which shake it up, you’ll see that there’s a dispersion of oil droplets within the water. When you cease shaking, they start to separate once more. The purpose of water solubility is to stop this remaining stage from occurring. Generally certainly one of two components are used to attain this everlasting dispersal:

  1. Surfactant – Compounds that decrease the floor pressure between two liquids or between a liquid and a stable.
  2. Emulsifier – Additive that helps two liquids combine by producing or stabilizing emulsion. Technically, it’s a class of surfactant. An emulsifier is made up of a hydrophilic head and hydrophobic tail; the pinnacle connects to the water, the tail to the oil. The emulsifier reduces floor pressure between the 2 liquids, thus stabilizing emulsion.

There are 4 fundamental strategies for creating water-soluble CBD.

Nanoemulsions and Nanoparticles

These are the preferred strategies used at present to enhance solubility; nevertheless, they don’t seem to be exactly the identical, so you will need to differentiate the 2.

  • Nanoparticles – These are sometimes energetic ingredient and provider particles which can be dispersed via ultrasonication (sound waves/frequencies) to disrupt the particle dimension of each the CBD and the provider. This breaks down the molecules into smaller and smaller items often called nanoparticles. These are nonetheless composed of the provider and energetic ingredient however are far smaller, and thus are extra able to passing via membrane partitions on this diminished state.
  • Nanoemulsions – These are a combination of the nanoparticles and emulsions of surfactant droplets created to scale back the floor pressure of the liquid oils, thus additional bettering bioavailability. This course of permits the nanoparticles to keep away from absorption within the abdomen by coming into the bloodstream instantly. Consequently, the CBD oil can work faster and extra successfully. Water-soluble CBD oil created by way of nanoemulsion is often tasteless and could be simply added to meals or drinks.

A 2013 research discovered that nano-emulsifying drug supply techniques have been, “Accountable for improved bioavailability and diminished variability of Class-2 compounds by SNEDDS: elevated solubilization diminished intra enterocyte metabolism and diminished P-gp efflux. SNEDDS impact is reversible and doesn’t trigger intestinal tissue or cell harm.”


This technique makes use of emulsions of 1 micron (1/1000 millimeter) sized drops of provider oil and surfactants. It tends to be unstable and separates into an oil layer on the prime and a water layer on the backside, with a combination in between. As a consequence of this lack of stability, this technique shouldn’t be excellent, however it’s an okay at-home repair and works decently with a sublingual dose.


This technique makes use of emulsion droplets which can be simply 10% the dimensions of the macroemulsion. As a result of they’re smaller, they’re extra steady than their bigger counterparts; nevertheless, this technique shouldn’t be very fashionable, particularly when in comparison with nanoemulsions. The big variety of surfactants can go away a nasty style or lead to well being issues or disagreeable results.

Liposomal CBD

Liposomes are fabricated from a drug supply system which can be small spherical constructions that include a hydrophilic outer layer and hydrophobic bilayer. This permits the carriers to encapsulate CBD molecules, thus making a liposomic switch. This course of may be very complicated and requires a lot of surfactants. Whereas this technique has the potential to realize floor throughout the CBD trade, the know-how round liposomal CBD remains to be comparatively new.

Advantages of Water-Soluble CBD

As famous, water-soluble CBD, particularly that created by nanoemulsion, is essentially the most environment friendly supply technique for CBD oil. This enhanced effectivity leads to two fundamental advantages:

  1. The CBD is absorbed faster and extra successfully, thus bettering any potential results.
  2. The CBD treatment is extra reasonably priced because you want much less of it to attain the supposed results.
  3. Water-Soluble CBD is extra protected as a result of giving the physique much less to succeed in the specified impact.  We must always solely give the physique what it wants and solely what it may deal with. An excessive amount of of something, even CBD, can turn out to be poisonous.  

Water-soluble CBD gives a number of further advantages, similar to:

  • It’s extra bioavailable than the water-insoluble CBD merchandise at present in the marketplace.
  • It’s a simple technique for administering CBD.
  • The potential therapeutic results of the CBD are felt a lot sooner.
  • A vial of CBD oil lasts for much longer since drops are extra environment friendly.
  • It’s a greater method to obtain a dependable dose every time you employ the CBD.
  • There may be improved comfort, which lets you carry the CBD oil with you and add it to your personal meals or drinks.

BioCBD+ Water-Soluble CBD Oil

BioCBD+ provides an all-natural, plant-based water-soluble CBD formulation for our capsules. Our proprietary, award-winning CBD formulations are made out of agricultural hemp. Subsequently, they include non-detectable quantities of THC, which implies that it’s 100% authorized and won’t lead to any psychoactive results frequent to THC.  

BioCBD+ has all the time endeavored to be on the forefront of technological change. Via the usage of hybrid nanoengineering, now we have helped to revolutionize the water-soluble CBD market. We’re assured that our all-natural merchandise make the most of the most effective and most secure supply of water-soluble CBD out there at present. Our CBD merchandise include no:

  • Glycerin
  • Toxins
  • GMOs
  • Liposomes
  • Pesticides
  • Gluten
  • Sugar
  • Synthetic coloring or flavoring

BioCBD+ Whole Physique Care CBD Capsules

The BioCBD+ Whole Physique Care CBD Capsules additionally function water-soluble formulations which can be 5 to 10 instances extra bioavailable than any oil-based CBD in the marketplace. We attribute this to a number of water-soluble energetic elements together with:

  • Hemp-Derived Natural CBD – Our CBD is fabricated from the best organically-grown hemp, which is cultivated in America and Northern Europe. There are not any low-cost isolates; we make the most of the total spectrum plant that’s triple examined to make sure 99.9% purity.
  • Magnesium – Magnesium is a crucial mineral and electrolyte that aids in enzyme, muscle, and nerve perform and can also be a precursor for serotonin.
  • Curcumin – A part of turmeric root, Curcumin has each antioxidant and anti inflammatory properties. It’s been valued in Ayurvedic medication for over 5,000 years.  That is additionally the ‘secret sauce’ that we use in our patent pending know-how.

A 2018 research entitled, Cannabinoid Supply Programs for Ache and Irritation Remedy, acknowledged the next, “There’s a rising physique of proof to recommend that cannabinoids are useful for a variety of scientific situations, together with ache, irritation, epilepsy, sleep issues, the signs of a number of sclerosis, anorexia, schizophrenia, and different situations.” 

In case you expertise muscle ache, joint ache, nervousness, despair, epilepsy, insomnia, or a bunch of different points, BioCBD+ could possibly enable you to.

As well as, as illustrated within the 507 patent, CBD may additionally be used to:

  • Enhance antioxidants
  • Enhance neuroprotectants
  • Probably assist in occasions of stroke and trauma
  • Probably ease neurodegenerative illnesses similar to Alzheimer’s illness, Parkinson’s, HIV, or Dementia
  • Probably support in treating inflammatory and autoimmune illnesses

Water Solubility and CBD

In summation, not all CBD is water-soluble. In its pure state, CBD oil doesn’t combine with water. Consequently, a lot of the oil doesn’t enter the bloodstream and as an alternative will get expelled or saved into fat. To extend bioavailability, nanoemulsion has turn out to be the most typical answer for lowering CBD oil’s hydrophobic response to water.

It’s necessary to search out CBD oil merchandise which can be water-soluble if you would like a product that’s efficient in your physique and your pockets. Water-soluble CBD merchandise like these from BioCBD+ have been created to boost the results of CBD, thereby bettering your expertise with the product and making the acquisition more cost effective general.

BioCBD+ respects and appreciates the onerous work the FDA does, and the disclosure beneath is required by  The Federal Meals, Drug and Beauty Act.

FDA Disclosure:

The statements made relating to these merchandise haven’t been evaluated by the Meals and Drug Administration. The efficacy of those merchandise has not been confirmed by FDA-approved analysis. These merchandise will not be supposed to diagnose, deal with, remedy or forestall any illness. All data offered right here shouldn’t be meant as an alternative choice to or different to data from healthcare practitioners. Please seek the advice of your healthcare skilled about potential interactions or different attainable issues earlier than utilizing any product.


  1. Cecchini, M. NCBI. Drug Residues Retailer within the Physique Following Cessation of Use. (2006).
  2. Huestis, M. NCBI. Human Cannabinoid Pharmacokinetics. (2009).
  3. Elgart, A. NCBI. Improved Oral Bioavailability of BCS Class 2 Compounds by Self Nano-Emulsifying Drug Supply Programs. (2013).
  4. Bruni, N. NCBI. Cannabinoid Supply Programs for Ache and Irritation Remedy. (2018).
  5. Aidan, J. U.S. Patent Software.  Cannabinoids as Antioxidants and Neuroprotectants.


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